Affiliation:
1. Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University Xining China
2. Department of Breast Medical Oncology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan China
Abstract
AbstractObjectivesThis study aimed to assess the overall incidence of osteonecrosis of the jaw (ONJ) caused by bisphosphonates and denosumab when used for controlling bone cancer metastasis or as adjuvant therapy.Subjects and MethodsA systematic search of the PubMed, Embase, and Cochrane Library databases and major meetings’ proceedings as of July 30, 2022, identified randomized controlled trials (RCTs) and observational trials that evaluated ONJ caused by denosumab or bisphosphonates. The total incidence and risk ratio (RR) for ONJ were calculated using a random‐effects model.ResultsA total of 42 003 patients with various solid tumors reported in 23 RCTs were included. The overall ONJ incidence in cancer patients receiving denosumab or bisphosphonates was 2.08% (95% CI 1.37–2.91; p < .01; I2 = 94.99%). Patients receiving denosumab had a higher ONJ incidence than those receiving bisphosphonates (RR 1.64, 95% CI 1.10–2.44; p < .05; I2 = 65.4%). Subgroup analyses showed that prostate cancer patients receiving denosumab and receiving zoledronic acid had the highest ONJ incidences, 5.0% and 3.0%, respectively. The incidence of ONJ induced by different doses was also different.ConclusionsThe incidence of ONJ caused by denosumab and bisphosphonates is low, the dose of the drug and the type of cancer have certain influence on ONJ. Therefore, clinicians should use the drug reasonably to improve the quality of life of patients.
Reference49 articles.
1. Bone sialoprotein and osteopontin in bone metastasis of osteotropic cancers
2. Mechanism of action pharmacokinetic and pharmacodynamic profile and clinical applications of nitrogen‐containing bisphosphonates ‐ PubMed. Accessed October 17 2022.https://pubmed.ncbi.nlm.nih.gov/17959891/
3. Adjuvant bisphosphonate treatment in early breast cancer: meta‐analyses of individual patient data from randomised trials ‐ PubMed. Accessed October 17 2022.https://pubmed.ncbi.nlm.nih.gov/26211824/
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