Clinicopathologic conference: Bloodstream infection in an allogeneic hamatopoietic cell transplant: Thinking beyond the usual-Reference-Cited by-同舟云学术

Clinicopathologic conference: Bloodstream infection in an allogeneic hamatopoietic cell transplant: Thinking beyond the usual

Published:2024-05-02 Issue:4 Volume:26 Page:
ISSN:1398-2273
Container-title:Transplant Infectious Disease
language:en
Short-container-title:Transplant Infectious Dis

Author:

Yeoh Kim¹²^ORCID,Lass‐Flörl Cornelia³,Lamoth Frédéric⁴⁵^ORCID,Slavin Monica A²⁶⁷⁸^ORCID,Williams Eloise¹²,Neofytos Dionysios⁹^ORCID

Affiliation:

1. Department of Microbiology The Royal Melbourne Hospital Melbourne Australia

2. Department of Infectious Diseases University of Melbourne at the Peter Doherty Institute for Infection and Immunity Melbourne Australia

3. Department of Hygiene Microbiology and Social Medicine Institute of Hygiene and Medical Microbiology Medical University of Innsbruck Innsbruck Austria

4. Department of Medicine Service of Infectious Diseases Lausanne University Hospital and University of Lausanne Lausanne Switzerland

5. Department of Laboratory Medicine and Pathology Institute of Microbiology Lausanne University Hospital and University of Lausanne Lausanne Switzerland

6. Department of Infectious Diseases, and National Centre for Infections in Cancer Peter MacCallum Cancer Centre Melbourne Australia

7. Sir Peter MacCallum Department of Oncology University of Melbourne Parkville Australia

8. Victorian Infectious Diseases Service Royal Melbourne Hospital Melbourne Australia

9. Division of Infectious Diseases University Hospital of Geneva Geneva Switzerland

Abstract

AbstractThis case involves a 53‐year‐old female with concurrent acute myeloid leukemia (AML) and multiple myeloma. She underwent cytarabine and daunorubicin (7+3) induction chemotherapy followed by cytarabine (HiDAC) consolidation, with an early AML relapse requiring azacitidine and venetoclax therapy. She achieved complete remission and incomplete count recovery. Following fludarabine, melphalan, and thymoglobulin induction chemotherapy, she underwent an allogeneic stem cell transplant with failure to engraft, requiring autologous stem cell rescue, buffy coat, and granulocyte transfusions, eventually presenting with a diffuse skin rash consistent with Steven‐Johnson syndrome and toxic epidermal necrolysis, persistent neutropenic fevers and positive blood cultures.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/tid.14273

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