Discovery and bio-optimization of human antibody therapeutics using the XenoMouse®transgenic mouse platform

Author:

Foltz Ian N.1,Gunasekaran Kannan2,King Chadwick T.1

Affiliation:

1. Amgen British Columbia; Burnaby BC Canada

2. Amgen Inc.; Thousand Oaks CA USA

Funder

Amgen

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference73 articles.

1. Reichert JM Therapeutic monoclonal antibodies approved or in review in the European Union or United States https://www.antibodysociety.org/news/approved_mabs.php

2. Transgenic mouse strains as platforms for the successful discovery and development of human therapeutic monoclonal antibodies;Green;Curr Drug Discov Technol,2014

3. A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates;Chan;Proc Natl Acad Sci U S A,2009

4. Kinetic analysis of unpurified native antigens available in very low quantities and concentrations;Rathanaswami;Anal Biochem,2011

5. Roskos L Foltz I King C Amgen Fremont, Inc, Antibodies directed to parathyroid hormone (PTH) and uses thereof

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