Biological concepts in human sodium channel epilepsies and their relevance in clinical practice

Author:

Brunklaus Andreas12ORCID,Du Juanjiangmeng3,Steckler Felix12,Ghanty Ismael I.12,Johannesen Katrine M.45ORCID,Fenger Christina Dühring46,Schorge Stephanie78,Baez‐Nieto David9,Wang Hao‐Ran9,Allen Andrew9,Pan Jen Q.9,Lerche Holger10,Heyne Henrike91112,Symonds Joseph D.12,Zuberi Sameer M.12,Sanders Stephan13,Sheidley Beth R.14,Craiu Dana1516,Olson Heather E.14,Weckhuysen Sarah171819,DeJonge Peter171819,Helbig Ingo2021222324,Van Esch Hilde25,Busa Tiffany26,Milh Matthieu2728,Isidor Bertrand29,Depienne Christel3031,Poduri Annapurna1432ORCID,Campbell Arthur J.8,Dimidschstein Jordane9,Møller Rikke S.45ORCID,Lal Dennis39113334

Affiliation:

1. Paediatric Neurosciences Research Group Royal Hospital for Children Glasgow UK

2. School of Medicine University of Glasgow Glasgow UK

3. Cologne Center for Genomics University of Cologne University Hospital Cologne Cologne Germany

4. Deparment of Epilepsy Genetics and Personalized Medicine Danish Epilepsy Center Filadelfia Dianalund Denmark

5. Institute for Regional Health Services University of Southern Denmark Odense Denmark

6. Amplexa Genetics Odense Denmark

7. Department of Clinical and Experimental Epilepsy Institute of Neurology University College London London UK

8. School of Pharmacy University College London London UK

9. Stanley Center for Psychiatric Research Broad Institute of Massachusetts Institute of Technology and Harvard Cambridge Massachusetts

10. Department of Neurology and Epileptology Hertie Institute for Clinical Brain Research University of Tübingen Germany

11. Analytic and Translational Genetics Unit Massachusetts General Hospital Boston Massachusetts

12. Institute for Molecular Medicine Finland University of Helsinki Helsinki Finland

13. Department of Psychiatry UCSF Weill Institute for Neurosciences University of California, San Francisco San Francisco California

14. Epilepsy Genetics Program Division of Epilepsy and Clinical Neurophysiology Department of Neurology Boston Children's Hospital Boston Massachusetts

15. Carol Davila University of Medicine Department of Clinical Neurosciences Pediatric Neurology Discipline Bucharest Romania

16. Alexandru Obregia Hospital Pediatric Neurology Clinic Bucharest Romania

17. Neurogenetics Group Center for Molecular Neurology VIB Antwerp Belgium

18. Laboratory of Neurogenetics Institute Born‐Bunge University of Antwerp Antwerp Belgium

19. Department of Neurology University Hospital Antwerp Antwerp Belgium

20. Division of Neurology Children's Hospital of Philadelphia Philadelphia Pennsylvania

21. Epilepsy NeuroGenetics Initiative Children's Hospital of Philadelphia Philadelphia Pennsylvania

22. Department of Biomedical and Health Informatics Children's Hospital of Philadelphia Philadelphia Pennsylvania

23. Department of Neurology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania

24. Department of Neuropediatrics University of Kiel Kiel Germany

25. Department of Human Genetics and Center for Human Genetics Laboratory for Genetics of Cognition University Hospitals Leuven Leuven Belgium

26. Genetics Department Timone Enfants University Hospital Center Public Assistance–Marseille Hospitals Marseille France

27. Medical Genetics and Functional GenomicsNational Institute of Health and Medical ResearchMixed Unit of Research S910Aix‐Marseille University Marseille France

28. Hematology Laboratory Le Mans Hospital Center Le Mans France

29. Medical Genetics Department Nantes University Hospital Center Nantes France

30. Institute of Human Genetics Essen University Hospital Essen Germany

31. Brain and Spinal Cord Institute National Institute of Health and Medical ResearchUnit 1127National Center for Scientific ResearchMixed Unit of Research 7225Sorbonne UniversitiesPierre and Marie Curie UniversityMixed Unit of Research S 1127Brain & Spine Institute Paris France

32. Harvard Medical School Boston Massachusetts

33. Epilepsy Center Neurological Institute Cleveland Clinic Cleveland Ohio

34. Genomic Medicine Institute Lerner Research Institute, Cleveland Clinic Cleveland Ohio

Funder

Wellcome Trust

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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