Unexpectedly high affinity of a novel histamine H3receptor antagonist, GSK239512,in vivoin human brain, determined using PET-Reference-Cited by-同舟云学术

Unexpectedly high affinity of a novel histamine H3receptor antagonist, GSK239512,in vivoin human brain, determined using PET

Author:

Ashworth S¹,Berges A²,Rabiner E A¹³,Wilson A A⁴,Comley R A¹,Lai R Y K⁵,Boardley R⁶,Searle G¹,Gunn R N¹³,Laruelle M¹³,Cunningham V J¹³⁷

Affiliation:

1. GlaxoSmithKline Clinical Imaging Centre; London UK

2. GlaxoSmithKline Clinical Pharmacology Modelling & Simulation; Stockley Park UK

3. Department of Medicine; Imperial College; London UK

4. The Centre for Addiction and Mental Health (CAMH); Toronto ON Canada

5. GlaxoSmithKline Neurosciences Discovery Medicine; Harlow UK

6. GlaxoSmithKline Clinical Pharmacology Science & Study Operations; Stevenage UK

7. Aberdeen Biomedical Imaging Centre, Institute of Medical Sciences; University of Aberdeen; Aberdeen UK

Publisher

Wiley

Subject

Pharmacology

Link

Reference37 articles.

1. Population pharmacokinetics: theory and practice;Aarons;Br J Clin Pharmacol,1991

5. Beal S Sheiner LB 1998 NONMEM User Guides (Nonmem Project Group)

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