The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice
Author:
Affiliation:
1. Department of Medicinal Chemistry; University of Vienna; Vienna Austria
2. Department of Pharmacology, Toxicology and Pharmacy; University of Veterinary Medicine Hannover; Hannover Germany
3. Center for Systems Neuroscience; Hannover Germany
Funder
Deutsche Forschungsgemeinschaft
Publisher
Wiley
Subject
Neurology (clinical),Neurology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/epi.13346/fullpdf
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4. The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures;Kahle;Neurosurg Focus,2008
5. Blocking seizures with the diuretic bumetanide: promises and pitfalls;Ben Ari;Epilepsia,2012
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