Proton beam therapy in paediatric cancer: Anticipating the opening of the Australian Bragg Centre for Proton Therapy and Research

Author:

Khong Jeremy1ORCID,Tee Hui12,Gorayski Peter1234ORCID,Le Hien1234,Penniment Michael123,Jessop Sophie5,Hansford Jordan256,Penfold Melanie23,Green Julia23,Skelton Kelly1234,Saran Frank1234ORCID

Affiliation:

1. Royal Adelaide Hospital Adelaide South Australia Australia

2. South Australia Health and Medical Research Institute Adelaide South Australia Australia

3. Australian Bragg Centre for Proton Therapy and Research Adelaide South Australia Australia

4. Allied Health and Human Performance Academic Unit University of South Australia Adelaide South Australia Australia

5. Michael Rice Centre for Haematology and Oncology, Women's and Children's Hospital Adelaide South Australia Australia

6. South Australia ImmunoGenomics Cancer Institute University of Adelaide Adelaide South Australia Australia

Abstract

SummaryProton Beam Therapy (PBT) has the potential to improve paediatric cancer care by reducing radiation exposure and thus long‐term toxicities. Ethical concerns and debates surrounding the treatment, such as eligibility and accessibility, are ongoing in Australia. The Australian Bragg Centre for Proton Therapy and Research (ABCPTR) (named after Sir William Henry Bragg who described the Bragg peak in his laboratory at the University of Adelaide in 1903) aims to increase access to PBT in Australasia and offer a patient‐centred care approach. Research is underway to assess PBT's safety and cost‐effectiveness, using tools including Normal Tissue Complication Probability (NTCP) models. Collaborative efforts are focused on developing tailored survivorship clinics to enhance patient follow‐up and quality of life. With the anticipated opening of the ABCPTR, Australia is preparing to take a significant step in radiation oncology, offering new research opportunities and creating a publicly funded treatment centre. The initiative aims to balance treatment efficacy with patient care, setting the stage for a future in which radiation therapy will reduce long‐term side effects compared to the current standard of care. The implementation of PBT in Australia represents a complex and promising approach to paediatric oncology. This article provides an overview of the current landscape, highlighting the potential benefits and challenges of a treatment that could redefine the quality of survivorship and contribute to global research and best clinical practice.

Publisher

Wiley

Subject

Radiology, Nuclear Medicine and imaging,Oncology

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