White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease: results from the Ontario Neurodegenerative Diseases Research Initiative-Reference-Cited by-同舟云学术

White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease: results from the Ontario Neurodegenerative Diseases Research Initiative

Published:2023-02-14 Issue:4 Volume:30 Page:920-933
ISSN:1351-5101
Container-title:European Journal of Neurology
language:en
Short-container-title:Euro J of Neurology

Author:

Carvalho de Abreu Daniela Cristina¹²^ORCID,Pieruccini‐Faria Frederico¹³^ORCID,Sarquis‐Adamson Yanina³,Black Alanna³,Fraser Julia⁴,Van Ooteghem Karen⁴,Cornish Benjamin⁴,Grimes David⁵,Jog Mandar⁶,Masellis Mario⁷⁸,Steeves Thomas⁹,Nanayakkara Nuwan¹⁰,Ramirez Joel⁸,Scott Christopher⁸,Holmes Melissa⁸,Ozzoude Miracle⁸,Berezuk Courtney⁸,Symons Sean⁸,Mohammad Hassan Haddad Seyyed¹⁰,Arnott Stephen R.¹¹,Binns Malcolm¹¹,Strother Stephen¹¹,Beaton Derek¹¹,Sunderland Kelly¹¹,Theyers Athena¹¹,Tan Brian¹¹,Zamyadi Mojdeh¹¹,Levine Brian¹¹,Orange Joseph B.¹²,Roberts Angela C.¹²¹³,Lou Wendy¹⁴,Sujanthan Sujeevini¹⁵,Breen David P.¹⁶¹⁷¹⁸^ORCID,Marras Connie¹⁹,Kwan Donna²⁰,Adamo Sabrina²¹,Peltsch Alicia²²,Troyer Angela K.²³,Black Sandra E.⁸,McLaughlin Paula M.²⁴,Lang Anthony E.²⁵,McIlroy William⁴,Bartha Robert²⁶,Montero‐Odasso Manuel¹³²⁷^ORCID,

Affiliation:

1. Gait and Brain Lab, Division of Geriatric Medicine, and Lawson Health Research Institute, Parkwood Institute University of Western Ontario Ontario London Canada

2. Department of Physical Therapy, Ribeirão Preto Medical School University of São Paulo São Paulo Brazil

3. Gait and Brain Laboratory Lawson Health Research Institute London Ontario Canada

4. Neuroscience, Mobility and Balance Laboratory, Department of Kinesiology and Health Sciences University of Waterloo Waterloo Ontario Canada

5. Department of Medicine (Neurology) Ottawa Hospital Research Institute, University of Ottawa Brain and Mind Research Institute Ottawa Ontario Canada

6. Division of Neurology, Department of Medicine, Schulich School of Medicine and Dentistry Western University London Ontario Canada

7. Cognitive and Movement Disorders Clinic, Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre University of Toronto Toronto Ontario Canada

8. L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Department of Medicine (Neurology), Sunnybrook Research Institute, Sunnybrook HSC University of Toronto Toronto Ontario Canada

9. Division of Neurology, Department of Medicine St Michael's Hospital and University of Toronto Toronto Ontario Canada

10. Robarts Research Institute, Schulich School of Medicine and Dentistry Western University London Ontario Canada

11. Rotman Research Institute at Baycrest Hospital University of Toronto Toronto Ontario Canada

12. School of Communication Sciences and Disorders, Faculty of Health Sciences, Canadian Centre for Activity and Aging Western University London Ontario Canada

13. Department of Computer Science Western University London Ontario Canada

14. Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada

15. Department of Ophthalmology and Visual Sciences Research Institute of the McGill University Health Center Montreal Quebec Canada

16. Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK

17. Anne Rowling Regenerative Neurology Clinic University of Edinburgh Edinburgh UK

18. Usher Institute of Population Health Sciences and Informatics University of Edinburgh Edinburgh UK

19. Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital University of Toronto Toronto Ontario Canada

20. Centre for Neuroscience Studies Queen's University Kingston Ontario Canada

21. Graduate Department of Psychological Clinical Science University of Toronto Scarborough Toronto Ontario Canada

22. Faculty of Engineering and Applied Science, Queen's University Kingston Ontario Canada

23. Neuropsychology and Cognitive Health Program, Baycrest Health Sciences, Department of Psychology University of Toronto Toronto Ontario Canada

24. Nova Scotia Health Halifax Nova Scotia, Canada

25. Division of Neurology, Department of Medicine, Edmond J Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital University of Toronto Toronto Ontario Canada

26. Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Robarts Research Institute Western University London Canada

27. Division of Geriatric Medicine, Department of Medicine, Schulich School of Medicine and Dentistry Western University London Ontario Canada

Abstract

AbstractBackground and purposeThe pathophysiology of Parkinson's disease (PD) negatively affects brain network connectivity, and in the presence of brain white matter hyperintensities (WMHs) cognitive and motor impairments seem to be aggravated. However, the role of WMHs in predicting accelerating symptom worsening remains controversial. The objective was to investigate whether location and segmental brain WMH burden at baseline predict cognitive and motor declines in PD after 2 years.MethodsNinety‐eight older adults followed longitudinally from Ontario Neurodegenerative Diseases Research Initiative with PD of 3–8 years in duration were included. Percentages of WMH volumes at baseline were calculated by location (deep and periventricular) and by brain region (frontal, temporal, parietal, occipital lobes and basal ganglia + thalamus). Cognitive and motor changes were assessed from baseline to 2‐year follow‐up. Specifically, global cognition, attention, executive function, memory, visuospatial abilities and language were assessed as were motor symptoms evaluated using the Movement Disorder Society Unified Parkinson's Disease Rating Scale Part III, spatial–temporal gait variables, Freezing of Gait Questionnaire and Activities Specific Balance Confidence Scale.ResultsRegression analysis adjusted for potential confounders showed that total and periventricular WMHs at baseline predicted decline in global cognition (p < 0.05). Also, total WMH burden predicted the decline of executive function (p < 0.05). Occipital WMH volumes also predicted decline in global cognition, visuomotor attention and visuospatial memory declines (p < 0.05). WMH volumes at baseline did not predict motor decline.ConclusionWhite matter hyperintensity burden at baseline predicted cognitive but not motor decline in early to mid‐stage PD. The motor decline observed after 2 years in these older adults with PD is probably related to the primary neurodegenerative process than comorbid white matter pathology.

Funder

Bruyère Research Institute

Centre for Addiction and Mental Health Foundation

Faculty of Health Sciences, Queen's University

Ontario Brain Institute

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/ene.15692

Reference51 articles.