Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

Author:

Elmore Monica R. P.12,Hohsfield Lindsay A.12,Kramár Enikö A.1,Soreq Lilach34,Lee Rafael J.12,Pham Stephanie T.12,Najafi Allison R.12,Spangenberg Elizabeth E.12,Wood Marcelo A.1,West Brian L.5,Green Kim N.12

Affiliation:

1. Department of Neurobiology and Behavior; University of California; Irvine California

2. Institute for Memory Impairments and Neurological Disorders (UCI MIND); Irvine California

3. University College London; London UK

4. The Francis Crick Institute; London UK

5. Plexxikon Inc; Berkeley California

Funder

National Institute on Aging

Glenn Family Foundation

National Institute of Neurological Disorders and Stroke

Alzheimer's Association

Alzheimer's Society UK

American Foundation for Aging Research

Publisher

Wiley

Subject

Cell Biology,Ageing

Reference48 articles.

1. Migration and differentiation of neural precursor cells can be directed by microglia;Aarum;Proceedings of the National Academy of Sciences,2003

2. Synaptic vesicle pools and dynamics;Alabi;Cold Spring Harbor Perspectives in Biology,2012

3. Neuroinflammation in the normal aging hippocampus;Barrientos;Neuroscience,2015

4. Microtubule plus-end tracking protein CLASP2 regulates neuronal polarity and synaptic function;Beffert;Journal of Neuroscience,2012

5. New tools for studying microglia in the mouse and human CNS;Bennett;Proceedings of the National Academy of Sciences of the USA,2016

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