Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis-Reference-Cited by-同舟云学术

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis

Published:2013-06 Issue:12 Volume:37 Page:1962-1969
ISSN:0953-816X
Container-title:European Journal of Neuroscience
language:en
Short-container-title:Eur J Neurosci

Author:

Deng Yu¹,Wang Zhe¹,Wang Ruitao¹,Zhang Xiaozhu¹,Zhang Shuting¹,Wu Yili¹,Staufenbiel Matthias²,Cai Fang¹,Song Weihong¹

Affiliation:

1. Department of Psychiatry; Townsend Family Laboratories; Brain Research Center; Graduate Program in Neuroscience; The University of British Columbia; 2255 Wesbrook Mall; Vancouver; BC; V6T 1Z3; Canada

2. Novartis Institutes for BioMedical Research Basel, Nervous System; Basel; Switzerland

Publisher

Wiley

Subject

General Neuroscience

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/ejn.12235/fullpdf

Reference45 articles.

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4. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice;Citron;Nat. Med.,1997

5. Translational regulation of BACE-1 expression in neuronal and non-neuronal cells;Pietri Tonelli;Nucleic Acids Res.,2004

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