Farnesoid X receptor activation induces the degradation of hepatotoxic 1‐deoxysphingolipids in non‐alcoholic fatty liver disease

Author:

Gai Zhibo12ORCID,Gui Ting1,Alecu Irina345,Lone Museer A.6,Hornemann Thorsten6,Chen Qingfa7,Visentin Michele2ORCID,Hiller Christian2,Hausler Stephanie2,Kullak‐Ublick Gerd A.28

Affiliation:

1. Key Laboratory of Traditional Chinese Medicine for Classical Theory Ministry of Education Shandong University of Traditional Chinese Medicine Jinan China

2. Department of Clinical Pharmacology and Toxicology University Hospital Zurich University of Zurich Zurich Switzerland

3. Neural Regeneration Laboratory Department of Biochemistry, Microbiology and Immunology Ottawa Institute of Systems Biology Ottawa ON Canada

4. Department of Cellular and Molecular Medicine uOttawa Brain and Mind Research Institute Ottawa ON Canada

5. Department of Chemistry and Biomolecular Sciences Centre for Catalysis and Research Innovation University of Ottawa Ottawa ON Canada

6. Department of Clinical Chemistry University Hospital Zurich University of Zurich Zurich Switzerland

7. The Institute for Tissue Engineering and Regenerative Medicine The Liaocheng University/Liaocheng People's Hospital Liaocheng China

8. Mechanistic Safety CMO & Patient Safety Global Drug Development Novartis Pharma Basel Switzerland

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

National Natural Science Foundation of China

Publisher

Wiley

Subject

Hepatology

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