Pharmacokinetic/pharmacodynamic drug-drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting drugs-Reference-Cited by-同舟云学术

Pharmacokinetic/pharmacodynamic drug-drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting drugs

Published:2018-02-20 Issue:5 Volume:84 Page:952-960
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Br J Clin Pharmacol

Author:

Nomoto Maiko¹^ORCID,Zamora Cynthia A.²,Schuck Edgar³,Boyd Peter⁴,Chang Min-Kun³,Aluri Jagadeesh³,Siu Y. Amy⁵,Lai W. George⁵,Yasuda Sanae¹,Ferry Jim³,Rege Bhaskar³

Affiliation:

1. Eisai Co., Ltd.; Tokyo Japan

2. Worldwide Clinical Trials; San Antonio TX USA

3. Eisai, Inc.; Woodcliff Lake NJ USA

4. Eisai Ltd; Hatfield UK

5. Eisai, Inc.; Andover MA USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcp.13517/fullpdf

Reference22 articles.

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3. Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor vortezomib;Uttamsingh;Drug Metab Dispos,2005

4. Pharmacokinetics, pharmacodynamics, pharmacogenomics, safety and tolerability of avatrombopag in healthy Japanese and Caucasian subjects;Nomoto;Clin Pharm Drug Dev,2018

5. European Medicines Agency Guideline on the investigation of drug interactions http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2012/07/WC500129606.pdf

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