A closer look at alcohol‐induced changes in the ghrelin system: novel insights from preclinical and clinical data

Author:

Deschaine Sara L.1ORCID,Farokhnia Mehdi123,Gregory‐Flores Adriana14,Zallar Lia J.14,You Zhi‐Bing5,Sun Hui6,Harvey Deon M.7,Marchette Renata C. N.24,Tunstall Brendan J.4ORCID,Mani Bharath K.8,Moose Jacob E.910,Lee Mary R.1ORCID,Gardner Eliot5,Akhlaghi Fatemeh11,Roberto Marisa12ORCID,Hougland James L.91013ORCID,Zigman Jeffrey M.81415,Koob George F.4,Vendruscolo Leandro F.4,Leggio Lorenzo12161718ORCID

Affiliation:

1. Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health Baltimore Maryland USA

2. Center on Compulsive Behaviors National Institutes of Health Bethesda Maryland USA

3. Johns Hopkins Bloomberg School of Public Health Johns Hopkins University Baltimore Maryland USA

4. Neurobiology of Addiction Section, Intramural Research Program National Institute on Drug Abuse, National Institutes of Health Baltimore Maryland USA

5. Neuropsychopharmacology Section, Molecular Targets and Medications Discovery Branch National Institute on Drug Abuse, National Institutes of Health Baltimore Maryland USA

6. Clinical Core Laboratory, Office of the Clinical Director National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health Bethesda Maryland USA

7. Office of the Scientific Director National Institute on Drug Abuse Baltimore Maryland USA

8. Center for Hypothalamic Research, Department of Internal Medicine UT Southwestern Medical Center Dallas Texas USA

9. Syracuse Biomaterials Institute Syracuse University Syracuse New York USA

10. Department of Chemistry Syracuse University Syracuse New York USA

11. Clinical Pharmacokinetics Research Laboratory, Department of Biomedical and Pharmaceutical Sciences University of Rhode Island Kingston Rhode Island USA

12. Department of Neuroscience The Scripps Research Institute La Jolla California USA

13. BioInspired Syracuse Syracuse University Syracuse New York USA

14. Division of Endocrinology, Department of Internal Medicine UT Southwestern Medical Center Dallas Texas USA

15. Department of Psychiatry UT Southwestern Medical Center Dallas Texas USA

16. Medication Development Program National Institute on Drug Abuse Intramural Research Program, National Institutes of Health Baltimore Maryland USA

17. Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, School of Public Health Brown University Providence Rhode Island USA

18. Division of Addiction Medicine, Department of Medicine, School of Medicine Johns Hopkins University Baltimore Maryland USA

Funder

Brain and Behavior Research Foundation

National Center for Advancing Translational Sciences

National Institute of General Medical Sciences

National Institute on Alcohol Abuse and Alcoholism

National Institute of Development Administration

National Institutes of Health

Neuroscience Research Australia

University of Sydney

Publisher

Wiley

Subject

Psychiatry and Mental health,Pharmacology,Medicine (miscellaneous)

Reference105 articles.

1. SAMSHA.2018 National Survey on Drug Use and Health (NSDUH). Table 5.4A—Alcohol use disorder in past year among persons aged 12 or older by age group and demographic characteristics: numbers in thousands 2017 and 2018.2018; Available from:https://www.samhsa.gov/data/sites/default/files/cbhsq‐reports/NSDUHDetailedTabs2018R2/NSDUHDetTabsSect5pe2018.htm#tab5‐4a

2. (CDC) C.f.D.C.a.P.Alcohol and public health: Alcohol‐Related Disease Impact (ARDI). Average for United States 2006–2010 alcohol‐attributable deaths due to excessive alcohol use. [cited20205/13/2020]; Available from:https://nccd.cdc.gov/DPH_ARDI/Default/Report.aspx?T=AAM%26P=f6d7eda7‐036e‐4553‐9968‐9b17ffad620e%26R=d7a9b303‐48e9‐4440‐bf47‐070a4827e1fd%26M=8E1C5233‐5640‐4EE8‐9247‐1ECA7DA325B9%26F=%26D

3. Role of Appetite-Regulating Peptides in the Pathophysiology of Addiction: Implications for Pharmacotherapy

4. Food addiction: a valid concept?

5. Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction

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