Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy

Author:

Prieto-Domínguez Néstor12,Ordóñez Raquel12,Fernández Anna12,Méndez-Blanco Carolina12,Baulies Anna23,Garcia-Ruiz Carmen23,Fernández-Checa José C.234,Mauriz José L.12,González-Gallego Javier12

Affiliation:

1. Institute of Biomedicine (IBIOMED); University of León; León Spain

2. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd); Spain

3. Department of Cell Death and Proliferation; Institute of Biomedical Research of Barcelona (IIBB); Consejo Superior Investigaciones Científicas (CSIC) and Liver Unit-Hospital Clinic; Barcelona Spain

4. University of Southern California Research Center for Alcohol Liver and Pancreatic Diseases and Cirrhosis; Keck School of Medicine; USC; Los Angeles CA USA

Funder

Instituto de Salud Carlos III

Plan Nacional de I+D Spain

National Institutes of Health

Generalitat de Catalunya

Ministry of Education of Spain

FPU

Publisher

Wiley

Subject

Endocrinology

Reference70 articles.

1. Global cancer statistics, 2012;Torre;CA Cancer J Clin,2015

2. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma;European Association for the Study of the Liver; European Organisation for Research and Treatment of Cancer;J Hepatol,2012

3. Hepatocellular carcinoma;Forner;Lancet,2012

4. New advances in hepatocellular carcinoma;Pascual;World J Hepatol,2016

5. Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial;Bruix;Lancet Oncol,2015

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