Discovery of Novel Secretory Phospholipase A2Inhibitors Using Virtual Screen

Author:

Qiu Shunchen1,Chen Fangjin2,Liu Ying12,Lai Luhua12

Affiliation:

1. BNLMS; State Key Laboratory of Structural Chemistry for Unstable and Stable Species; College of Chemistry and Molecular Engineering; Peking University; Beijing 100871 China

2. Center for Quantitative Biology; Peking University; Beijing 100871 China

Funder

National Natural Science Foundation of China

Ministry of Science and TEchnology, China

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference39 articles.

1. Characterization of a secretable phospholipase A2 from human platelets;Kramer;Adv Prostaglandin Thromboxane Leukot Res,1990

2. The expanding superfamily of phospholipase A(2) enzymes: classification and characterization;Six;Biochim Biophys Acta,2000

3. Phospholipase A(2) isoforms: a perspective;Chakraborti;Cell Signal,2003

4. Circulating secretory phospholipase A2 in critical illness - the importance of the intestine;Corke;Crit Care Resusc,2001

5. Phospholipase A2 inhibitors as potential anti-inflammatory agents;Meyer;Curr Pharm Des,2005

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