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An Open-label Phase 1 Dose-escalation Clinical Trial of a Single Intravenous Administration of Gemcitabine in Dogs with Advanced Solid Tumors

  • Published:2015-03 Issue:2 Volume:29 Page:620-625
  • ISSN:0891-6640
  • Container-title:Journal of Veterinary Internal Medicine
  • language:en
  • Short-container-title:J Vet Intern Med

Author:

Marconato L.1,Finotello R.2,Bonfanti U.3,Dacasto M.4,Beatrice L.1,Pizzoni S.1,Leone V.F.1,Balestra G.5,Furlanello T.5,Rohrer Bley C.2,Aresu L.4

Affiliation:

1. Centro Oncologico Veterinario; Sasso Marconi Italy

2. Division of Radiation Oncology; Vetsuisse Faculty; University of Zurich; Zurich Switzerland

3. Private Veterinary Laboratory “Biessea”; Milan Italy

4. Department of Comparative Biomedicine and Food Science; University of Padua; Padua Italy

5. Laboratorio d'Analisi Veterinarie San Marco; Padua Italy

Publisher

Wiley

Subject

General Veterinary

Reference18 articles.

1. Cellular elimination of 2′,2′-difluorodeoxycytidine 5′-triphosphate: A mechanism of self-potentiation;Heinemann;Cancer Res,1992

2. Gemcitabine: Metabolism, mechanisms of action and self-potentiation;Plunkett;Semin Oncol,1995

3. Clinical evaluation of gemcitabine in dogs with spontaneously occurring malignancies;Kosarek;J Vet Intern Med,2005

4. Single agent gemcitabine chemotherapy in dogs with spontaneously occurring lymphoma;Turner;J Vet Intern Med,2006

5. Adjuvant gemcitabine after surgical removal of aggressive malignant mammary tumours in dogs;Marconato;Vet Comp Oncol,2008

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