Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats

Author:

Klimas Jan1,Olvedy Michael1,Ochodnicka-Mackovicova Katarina1,Kruzliak Peter2,Cacanyiova Sona3,Kristek Frantisek3,Krenek Peter1,Ochodnicky Peter1

Affiliation:

1. Department of Pharmacology and Toxicology; Faculty of Pharmacy; Comenius University; Bratislava Slovakia

2. Department of Cardiovascular Diseases; International Clinical Research Centre; St. Anne′s University Hospital and Masaryk University; Brno Czech Republic

3. Institute of Normal and Pathological Physiology; Centre of Excellence for Cardiovascular Research; Slovak Academy of Sciences; Bratislava Slovakia

Funder

Slovak Research and Development Agency

Science Grant Agency

European Regional Development Fund

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Reference55 articles.

1. Angiotensin AT1 receptor antagonism and protection against cardiovascular end-organ damage;Nishikawa;J Hum Hypertens,1998

2. Temporary losartan or captopril in young SHR induces malignant hypertension despite initial normotension;Racasan;Kidney Int,2004

3. Fetal origins of adult hypertension: a renal mechanism?;Woods;Curr Opin Nephrol Hypertens,2000

4. Losartan's protective effects in stroke-prone spontaneously hypertensive rats persist durably after treatment withdrawal;Fornes;J Cardiovasc Pharmacol,1993

5. Increased salt intake during early ontogenesis lead to development of arterial hypertension in salt-resistant Wistar rats;Svitok;Clin Exp Hypertens,2014

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