Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Author:

Liu Jiyuan1,Yang Fan2,Hu Jinqu1ORCID,Zhang Xiuchun3ORCID

Affiliation:

1. Department of Neurosurgery the First Hospital of China Medical University Shenyang China

2. Department of Cardiology the Fourth Affiliated Hospital of China Medical University Shenyang China

3. Department of Neurology the First Hospital of China Medical University Shenyang China

Abstract

AbstractGliomas are the most common primary tumors of the central nervous system, with glioblastoma multiforme (GBM) having the highest incidence, and their therapeutic efficacy depends primarily on the extent of surgical resection and the efficacy of postoperative chemotherapy. The role of the intracranial blood–brain barrier and the occurrence of the drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited the efficacy of chemotherapeutic agents in patients with GBM and made it difficult to achieve the expected clinical response. In recent years, the rapid development of nanotechnology has brought new hope for the treatment of tumors. Nanoparticles (NPs) have shown great potential in tumor therapy due to their unique properties such as light, heat, electromagnetic effects, and passive targeting. Furthermore, NPs can effectively load chemotherapeutic drugs, significantly reduce the side effects of chemotherapeutic drugs, and improve chemotherapeutic efficacy, showing great potential in the chemotherapy of glioma. In this article, we reviewed the mechanisms of glioma drug resistance, the physicochemical properties of NPs, and recent advances in NPs in glioma chemotherapy resistance. We aimed to provide new perspectives on the clinical treatment of glioma.

Publisher

Wiley

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