Toxicity profile of repeated doses of PEG-asparaginase incorporated into a pediatric-type regimen for adult acute lymphoblastic leukemia

Author:

Aldoss Ibrahim1,Douer Dan2,Behrendt Carolyn E.3,Chaudhary Preeti4,Mohrbacher Ann4,Vrona Janice4,Pullarkat Vinod1

Affiliation:

1. Department of Hematology and Hematopoietic Cell Transplantation; City of Hope National Medical Center; Duarte CA USA

2. Leukemia Service; Memorial Sloan Kettering Cancer Center; New York NY USA

3. Division of Biostatistics; Department of Information Sciences; City of Hope National Medical Center; Duarte CA USA

4. Jane Ann Nohl Division of Hematology; University of Southern California Keck School of Medicine; Los Angeles CA USA

Funder

Sigma-Tau

Publisher

Wiley

Subject

Hematology,General Medicine

Reference16 articles.

1. Pharmacokinetics-based integration of multiple doses of intravenous pegaspargase in a pediatric regimen for adults with newly diagnosed acute lymphoblastic leukemia;Douer;J Clin Oncol,2014

2. Long-term outcome of a pediatric-inspired regimen used for adults aged 18-50 years with newly diagnosed acute lymphoblastic leukemia;DeAngelo;Leukemia,2015

3. Asparaginases. biochemical pharmacology and modes of drug resistance;Avramis;Anticancer Res,2012

4. Pharmacodynamics and safety of intravenous pegaspargase during remission induction in adults aged 55 years or younger with newly diagnosed acute lymphoblastic leukemia;Douer;Blood,2007

5. Results of the PETHEMA ALL-96 trial in elderly patients with Philadelphia chromosome-negative acute lymphoblastic leukemia;Sancho;Eur J Haematol,2007

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