An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE

Author:

Josephs D. H.12,Nakamura M.1,Bax H. J.12,Dodev T. S.3,Muirhead G.4,Saul L.12,Karagiannis P.12,Ilieva K. M.15,Crescioli S.1,Gazinska P.56,Woodman N.6,Lombardelli C.6,Kareemaghay S.6,Selkirk C.7,Lentfer H.7,Barton C.8,Canevari S.9,Figini M.9,Downes N.10,Dombrowicz D.11,Corrigan C. J.12,Nestle F. O.113,Jones P. S.8,Gould H. J.3,Blower P. J.14,Tsoka S.4,Spicer J. F.2,Karagiannis S. N.15ORCID

Affiliation:

1. St. John's Institute of Dermatology; School of Basic & Medical Biosciences; King's College London; London UK

2. School of Cancer & Pharmaceutical Sciences; Guy's Hospital; King's College London; London UK

3. Randall Centre for Cell and Molecular Biophysics; King's College London; London UK

4. Department of Informatics; Faculty of Natural and Mathematical Sciences; King's College London; London UK

5. Breast Cancer Now Research Unit; School of Cancer & Pharmaceutical Sciences; Guy's Cancer Centre; King's College London; London UK

6. King's Health Partners Cancer Biobank; School of Cancer & Pharmaceutical Sciences; King's College London; London UK

7. Biotherapeutics Development Unit; Cancer Research UK; South Mimms UK

8. Centre for Drug Development; Cancer Research UK; London UK

9. Department of Applied Research and Technology Development; Fondazione IRCCS Istituto Nazionale dei Tumouri; Milan Italy

10. Sequani; Ledbury UK

11. CHU Lille; Institut Pasteur de Lille; Inserm; Univ. Lille; Lille France

12. Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma; King's College London; London UK

13. Immunology and Inflammation Therapeutic Research Area; Sanofi US; Cambridge MA USA

14. Imaging Chemistry & Biology; Division of Imaging Sciences and Biomedical Engineering; St. Thomas's Hospital; King's College London; London UK

Funder

Breast Cancer Now

CRUK/EPSRC/MRC/NIHR KCL/UCL Comprehensive Cancer Imaging Centre

Academy of Medical Sciences

Medical Research Council

Cancer Research UK

National Institute for Health Research

CRUK/NIHR in England/DoH for Scotland, Wales and Northern Ireland Experimental Cancer Medicine Centre

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference29 articles.

1. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412;Suntharalingam;N Engl J Med,2006

2. European Medicines Agency, Committee for Medicinal Products for Human Use (CHMP) Guideline on strategies to identify and mitigate risks for first-in-human and early clinical trials with investigational medicinal products 2017

3. Affinity of human IgG subclasses to mouse Fc gamma receptors;Dekkers;mAbs,2017

4. The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology;Kinet;Annu Rev Immunol,1999

5. Molecular structure and expression of the murine lymphocyte low-affinity receptor for IgE (Fc epsilon RII);Bettler;Proc Natl Acad Sci USA,1989

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