Affiliation:
1. Service d’Urologie, AP‐HP, Hôpital Tenon Sorbonne Université Paris France
2. GRC n°20, Groupe de Recherche Clinique sur la Lithiase Urinaire, Hôpital Tenon Sorbonne Université Paris France
3. PIMM, UMR 8006 CNRS, Arts et Métiers ParisTech Paris France
4. Service d’Urologie CHU de Poitiers Poitiers France
5. Service d’Urologie CHU de Limoges Limoges France
6. Service d’Anatomopathologie, AP‐HP, Hôpital Tenon Sorbonne Université Paris France
Abstract
ObjectivesTo assess laser–tissue interactions through ablation, coagulation, and carbonisation characteristics in a non‐perfused porcine kidney model between three pulsed lasers: holmium (Ho): yttrium‐aluminium‐garnet (YAG), thulium fiber laser (TFL), and pulsed thulium (p‐Tm):YAG.Materials and MethodsA 150‐W Ho:YAG, a 60‐W TFL, and a 100‐W p‐Tm:YAG lasers were compared. The laser settings that can be set identically between the three lasers and be clinically relevant for prostate laser enucleation were identified and used on fresh, unfrozen porcine kidneys. Laser incisions were performed using stripped laser fibers of 365 and 550 μm, set at distances of 0 and 1 mm from the tissue surface at a constant speed of 2 mm/s. Histological analysis evaluated shape, depth, width of the incision, axial coagulation depth, and presence of carbonisation.ResultsIncision depths, widths, and coagulation zones were greater with Ho:YAG and p‐Tm:YAG lasers than TFL. Although no carbonisation was found with the Ho:YAG and p‐Tm:YAG lasers, it was common with TFL, especially at high frequencies. The shapes of the incisions and coagulation zones were more regular and homogeneous with the p‐Tm:YAG laser and TFL than with Ho:YAG laser. Regardless of the laser used, short pulse durations resulted in deeper incisions than long pulse durations. Concerning the distance, we found that to be effective, TFL had to be used in contact with the tissue. Finally, 365‐μm fibers resulted in deeper incisions, while 550‐μm fibers led to wider incisions and larger coagulation zones.ConclusionHistological analysis revealed greater tissue penetration with the p‐Tm:YAG laser compared to the TFL, while remaining less than with Ho:YAG. Its coagulation properties seem interesting insofar as it provides homogeneous coagulation without carbonisation, while incisions remained uniform without tissue laceration. Thus, the p‐Tm:YAG laser appears to be an effective alternative to Ho:YAG and TFL lasers in prostate surgery.