Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation

Author:

Bieghs Veerle12,Walenbergh Sofie M. A.1,Hendrikx Tim1,van Gorp Patrick J.1,Verheyen Fons3,Olde Damink Steven W.45,Masclee Ad A.6,Koek Ger H.6,Hofker Marten H.7,Binder Christoph J.89,Shiri-Sverdlov Ronit1

Affiliation:

1. Department of Molecular Genetics; Maastricht University; Maastricht the Netherlands

2. Department of Internal Medicine; University Hospital (RWTH); Aachen Germany

3. Department of Electron Microscopy Unit; CRISP; Department of Molecular Cell Biology; Maastricht University; Maastricht the Netherlands

4. Department of General Surgery; Maastricht University; Maastricht the Netherlands

5. Department of HPB and Liver Transplantation Surgery; UCL Institute for Liver and Digestive Health; University College London Medical School; Royal Free Campus; London UK

6. Department of Internal Medicine; Division of Gastroenterology and Hepatology; Maastricht University Medical Centre (MUMC); Maastricht the Netherlands

7. Department of Pathology & Laboratory Medicine; University Medical Center Groningen; University of Groningen; Groningen the Netherlands

8. Department of Laboratory Medicine; Medical University of Vienna; Vienna Austria

9. Center for Molecular Medicine; Austrian Academy of Sciences; Vienna Austria

Funder

The Netherlands Organisation for Scientific Research

Publisher

Wiley

Subject

Hepatology

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