Assessment of left ventricular structure and function in preeclampsia subtypes by multimodal echocardiography

Abstract

AbstractAimTo explore left ventricular structural/functional abnormalities in preeclampsia patients by using multimodal echocardiography and to analyze the cardiac impact in preeclampsia subtypes.MethodsA total of 103 individuals, including 64 preeclampsia patients and 39 healthy pregnant women were recruited for this study from 2019 to 2021. There were 34 patients with preeclampsia with severe features (SPE) patients and 30 with preeclampsia with nonsevere features (NSPE), including 9 with early‐onset NSPE (EO‐NSPE) patients, 27 early‐onset SPE (EO‐SPE) patients, 21 later‐onset NSPE (LO‐NSPE), and 7 with later‐onset SPE (LO‐SPE). All patients underwent multimodal echocardiography before treatment, including two‐dimensional, Doppler, and speckle‐tracking echocardiography, to evaluate left ventricular structure/function. Analysis of variance was used to determine statistical significance across groups.ResultsEO‐SPE patients showed decreased left ventricular ejection fractions, peak longitudinal systolic strain at apical four‐chambers, peak circumferential, and radial systolic strain at the apical and mitral annular plane systolic excursion (MAPSE), and increased mitral regurgitation compared to other preeclampsia patients. Compared to LO‐NSPE and EO‐SPE patients, LO‐SPE patients showed increased left ventricular mass indexed to height2.7 and early diastolic left ventricular diastolic filling/mitral annular velocity, and decreased MAPSE and early/late diastolic mitral annular velocity.ConclusionEO‐SPE patients were characterized by left ventricular injury and systolic function reduced. LO‐SPE patients were characterized by left ventricular hypertrophy and reduced diastolic function. Multimodal echocardiography can detect myocardial injury in PE patients at an early stage.