Mild cognitive impairment is associated with passive suicidal ideation in older adults: A population‐based study

Author:

Rymo Irma12ORCID,Fässberg Madeleine Mellqvist1,Kern Silke13,Zetterberg Henrik45678,Skoog Ingmar13,Waern Margda19,Sacuiu Simona1310

Affiliation:

1. Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy Centre for Ageing and Health AGECAP at the University of Gothenburg Gothenburg Sweden

2. Addiction Disorders Clinic Sahlgrenska University Hospital, Region Västra Götaland Gothenburg Sweden

3. Psychiatry Cognition and Old Age Psychiatry Department in Mölndal Sahlgrenska University Hospital Region Västra Götaland Sweden

4. Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden

5. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden

6. UCL Institute of Neurology Department of Neurodegenerative Disease Queen Square London UK

7. UK Dementia Research Institute at UCL London UK

8. Hong Kong Center for Neurodegenerative Diseases Clear Water Bay Hong Kong China

9. Psychosis Department Sahlgrenska University Hospital, Region Västra Götaland Gothenburg Sweden

10. Cognitive Disorders Clinic, Theme Inflammation and Aging Karolinska University Hospital Stockholm Sweden

Abstract

AbstractObjectiveTo investigate the association between MCI and passive/active suicidal ideation in a population‐based sample of older adults.MethodThe sample included 916 participants without dementia acquired from the two population‐based studies Prospective Population Study of Women (PPSW) and the H70‐study. Cognitive status was assessed using a comprehensive neuropsychiatric examination and classified according to the Winblad et al. criteria: 182 participants were classified as cognitively intact, 448 had cognitive impairment but did not fulfill MCI criteria and 286 were diagnosed with MCI. Passive/active suicidal ideation was assessed using the Paykel questions.ResultsPassive or active suicidal ideation (any level) was reported by 16.0% of those with MCI and 1.1% of those who were cognitively intact. MCI was associated with past year life‐weariness (OR 18.32, 95% CI 2.44–137.75) and death wishes (OR 5.30, 95% CI 1.19–23.64) in regression models adjusted for covariates including major depression. Lifetime suicidal ideation was reported more frequently in MCI (35.7%) than in cognitively intact participants (14.8%). MCI was associated with lifetime life‐weariness (OR 2.90, 95% CI 1.67–5.05). Among individuals with MCI, impairments in memory and visuospatial ability were associated with both past year and lifetime life‐weariness.ConclusionOur findings suggest reports of past year as well as lifetime passive suicidal ideation to be more frequent among individuals with MCI compared to those cognitively intact, indicating that individuals with MCI may constitute a high‐risk group for suicidal behavior.

Funder

Alzheimer's Drug Discovery Foundation

Demensfonden

Demensförbundet

Hjärnfonden

Olav Thon Stiftelsen

Stiftelsen för Gamla Tjänarinnor

Stiftelsen Längmanska Kulturfonden

Stiftelsen Psykiatriska Forskningsfonden

Stiftelsen Söderström Königska Sjukhemmet

Publisher

Wiley

Subject

Psychiatry and Mental health

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