Additional evidence for a therapeutic effect of dextromethorphan/quinidine on bulbar motor function in patients with amyotrophic lateral sclerosis: A quantitative speech analysis

Author:

Green Jordan R.12,Allison Kristen M.13,Cordella Claire12,Richburg Brian D.1ORCID,Pattee Gary L.4,Berry James D.5,Macklin Eric A.67,Pioro Erik P.8,Smith Richard A.9

Affiliation:

1. Speech and Feeding Disorders Lab; MGH Institute of Health Professions; Charlestown MA USA

2. Program in Speech and Hearing Bioscience and Technology Program, Division of Medical Sciences; Harvard University; Boston MA USA

3. Department of Communication Sciences and Disorders, Bouve College of Health Sciences; Northeastern University; Boston MA USA

4. Department of Neurology; University of Nebraska Medical College; Omaha NE USA

5. Department of Neurology; Massachusetts General Hospital; Boston MA USA

6. Biostatistics Center; Massachusetts General Hospital; Boston MA USA

7. Department of Medicine; Harvard Medical School; Boston MA USA

8. Department of Neurology; Cleveland Clinic Neuromuscular Center; Cleveland OH USA

9. Center for Neurologic Study; La Jolla CA USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference38 articles.

1. A 24-week, phase III, double-blind, parallel-group study of edaravone (MCI-186) for treatment of amyotrophic lateral sclerosis (ALS)(P3. 189);Tanaka;Neurology,2016

2. A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group;Bensimon;N Engl J Med,1994

3. Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis;Ferraiuolo;Nat Rev Neurol,2011

4. Riluzole, neuroprotection and amyotrophic lateral sclerosis;Cheah;Curr Med Chem,2010

5. Enhanced bulbar function in amyotrophic lateral sclerosis: the Nuedexta treatment trial;Smith;Neurotherapeutics,2017

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