Affiliation:
1. College of Chemical and Environmental Engineering, Shanghai Institute of Technology Shanghai China
2. Department of Urology The First Affiliated Hospital of Nanchang University Nanchang China
Abstract
AbstractA new series of flavonoids and quinolone derivatives were designed, synthesized and, evaluated for their biological activity. Among them, compound 14e showed better inhibition potency against TNKS2 in comparison with G007‐LK, one of the most potent preclinical stage TNKS inhibitor. Molecular docking results showed that 14e occupied both the adenosine and nicotinamide pockets and formed a hydrogen bond with Met1054 of TNKS2. This study provides a lead for the design and discovery of potent and selective TNKS2 inhibitors.
Funder
National Natural Science Foundation of China
Subject
Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry
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