Characterizing the Free-Energy Landscape of MDM2 Protein-Ligand Interactions by Steered Molecular Dynamics Simulations-Reference-Cited by-同舟云学术

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Characterizing the Free-Energy Landscape of MDM2 Protein-Ligand Interactions by Steered Molecular Dynamics Simulations

Published:2015-06-15 Issue:6 Volume:86 Page:1351-1359
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Hu Guodong¹²,Xu Shicai¹²,Wang Jihua¹²

Affiliation:

1. Shandong Provincial Key Laboratory of Functional Macromolecular Biophysics; Dezhou University; Dezhou China

2. College of Physics and Electronic Information; Dezhou University; Dezhou China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

A Project of Shandong Province Higher Educational Science and Technology Program

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12598/fullpdf

Reference33 articles.

1. Surfing the p53 network;Vogelstein;Nature,2000

2. p53, the cellular gatekeeper for growth and division;Levine;Cell,1997

3. Cell fate decision mediated by p53 pulses;Zhang;Proc Natl Acad Sci U S A,2009

4. Two-phase dynamics of p53 in the DNA damage response;Zhang;Proc Natl Acad Sci U S A,2011

5. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2;Vassilev;Science,2004

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