Telangiectatic osteosarcoma in four dogs: Cytologic, histopathologic, cytochemical, and immunohistochemical findings

Author:

Cagle Laura A.1ORCID,Maisel Morgan1,Conrado Francisco O.2ORCID,Wait Courtney3,Peper Katherine3,Lochhead Tannis3,Vo Thao3,Dolan Jacqueline K.1,de Oliveira Helena Hauck1,Bosch Sarah1,Walker Randall1,Fox‐Alvarez Stacey A.3,Porter Erin3,Carrera‐Justiz Sheila3,Lanier Christopher J.1ORCID,Hoffmann Aline Rodrigues1,Dark Michael J.1,Sharkey Leslie C.4ORCID

Affiliation:

1. Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine University of Florida Gainesville Florida USA

2. Department of Comparative Pathobiology, Cummings School of Veterinary Medicine Tufts University North Grafton Massachusetts USA

3. Small Animal Clinical Sciences, College of Veterinary Medicine University of Florida Gainesville Florida USA

4. Department of Clinical Sciences, Cummings School of Veterinary Medicine Tufts University North Grafton Massachusetts USA

Abstract

AbstractTelangiectatic osteosarcoma is a rare variant of osteosarcoma histologically and clinically similar to hemangiosarcoma (HSA). This case series describes the imaging and cytologic features of four histologically confirmed telangiectatic osteosarcomas, including the use of cytochemical stains. Alkaline phosphatase (ALP) was applied to Wright–Giemsa‐stained cytology slides, and Factor VIII immunohistochemistry was evaluated. Cytologic characteristics included atypical mesenchymal cells with evidence of acute and chronic hemorrhage. Telangiectatic osteosarcoma cases had positive ALP cytochemical staining, while control HSA cases were negative. Factor VIII immunohistochemistry was negative in telangiectatic osteosarcoma and positive in HSA. Cytologic diagnosis of telangiectatic osteosarcoma with positive ALP cytochemical staining can help differentiate this neoplasm from HSA.

Publisher

Wiley

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