Effects of valsartan, benazepril and their combination in overt nephropathy of type 2 diabetes: A prospective, randomized, controlled trial

Author:

Ruggenenti Piero12,Trillini Matias1,P. Barlovic Drazenka3,Cortinovis Monica1,Pisani Antonio4,Parvanova Aneliya1,Iliev Ilian P.1,Ruggiero Barbara1,Rota Stefano2,Aparicio Maria C.1,Perna Annalisa1,Peraro Francesco1,Diadei Olimpia1,Gaspari Flavio1,Carrara Fabiola1,Stucchi Nadia1,Martinetti Davide1,Janez Andrej3,Gregoric Nadan3,Riccio Eleonora4,Bossi Antonio C.5,Trevisan Roberto6,Manunta Paolo7,Battaglia Giovanni8,David Salvatore9,Aucella Filippo10,Belviso Antonio11,Satta Andrea12,Remuzzi Giuseppe113ORCID,

Affiliation:

1. Department of Renal MedicineClinical Research Centre for Rare Diseases “Aldo e Cele Daccò”: Istituto di Ricerche Farmacologiche Mario Negri IRCCS Ranica (Bergamo) Italy

2. Unit of Nephrology and DialysisAzienda Socio‐Sanitaria Territoriale Papa Giovanni XXIII Bergamo Italy

3. Clinical Department of EndocrinologyDiabetes and Metabolic Diseases University Medical Centre Ljubljana Ljubljana Slovenia

4. Chair of Nephrology, Department of Public HealthFederico II University of Naples Naples Italy

5. Unit of Diabetology and Metabolic DiseasesAzienda Socio‐Sanitaria Territoriale Bergamo Ovest Treviglio‐Caravaggio‐Romano (Bergamo) Italy

6. Unit of Diabetology and EndocrinologyAzienda Socio‐Sanitaria Territoriale Papa Giovanni XXIII Bergamo Italy

7. Chair of Nephrology, Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute‐Chair of NephrologyUniversità Vita Salute San Raffaele Milan Italy

8. Department of Nephrology and DialysisHospital “S. Marta e S. Venera” Acireale (Catania) Italy

9. Department of Nephrology and DialysisHospital “Azienda Ospedaliera di Parma” Parma Italy

10. Department of Nephrology and Dialysis, Research Hospital “Casa Sollievo della Sofferenza” San Giovanni Rotondo (Foggia) Italy

11. Poliambulatorio Extra‐ospedalieroASST Bergamo Ovest Brembate di Sopra (Bergamo) Italy

12. Institute of Medical PathologyUniversity AUSL 1 Sassari Italy

13. L. Sacco, Department of Biomedical and Clinical ScienceUniversity of Milan Milan Italy

Funder

The Italian Medicines Agency

Novartis Italia

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference31 articles.

1. Diabetic Kidney Disease: A Report From an ADA Consensus Conference

2. United States Renal Data System:USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States Bethesda MD:National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases;2015.

3. Clinical Manifestations of Kidney Disease Among US Adults With Diabetes, 1988-2014

4. Nephropathy in Patients with Type 2 Diabetes

5. Economic Costs of Diabetes in the U.S. in 2017

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