Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M 1 ‐acetylcholine receptor agonist: A randomized cross‐over trial-Reference-Cited by-同舟云学术

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Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M 1 ‐acetylcholine receptor agonist: A randomized cross‐over trial

Published:2021-05-08 Issue:11 Volume:87 Page:4439-4449
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Br J Clin Pharmacol

Author:

Bakker Charlotte¹²^ORCID,Prins Samantha¹²,Liptrot Jan³,Hart Ellen P.¹,Klaassen Erica S.¹,Brown Giles A.³,Brown Alastair³,Congreve Miles³,Weir Malcolm³,Marshall Fiona H.³⁴,Stevens Jasper¹⁵^ORCID,Cross David M.⁶,Tasker Tim³,Nathan Pradeep J.³⁷⁸,Groeneveld Geert Jan¹²

Affiliation:

1. Centre for Human Drug Research Leiden The Netherlands

2. Leiden University Medical Center Leiden The Netherlands

3. Sosei Heptares Cambridge UK

4. MSD Research Laboratories (Merck & Co) Kenilworth New Jersey USA

5. University of Groningen University Medical Center Groningen Groningen The Netherlands

6. Cross Pharma Consulting Ltd Cambridge UK

7. Department of Psychiatry University of Cambridge Cambridge UK

8. School of Psychological Sciences Monash University Australia

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.14872

Reference49 articles.

1. Preventing cognitive decline in preclinical Alzheimer's disease

2. Pre- and post-synaptic cortical cholinergic deficits are proportional to amyloid plaque presence and density at preclinical stages of Alzheimer’s disease

3. Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

4. Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

5. Treatment of Alzheimers Disease: Symptomatic and Disease-Modifying Approaches

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