Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects-Reference-Cited by-同舟云学术

Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects

Published:2013-05-20 Issue:6 Volume:75 Page:1488-1496
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Br J Clin Pharmacol

Author:

Holmberg Mikko T.¹,Tornio Aleksi¹,Joutsi-Korhonen Lotta²,Neuvonen Mikko¹,Neuvonen Pertti J.¹,Lassila Riitta²,Niemi Mikko¹,Backman Janne T.¹

Affiliation:

1. Department of Clinical Pharmacology; University of Helsinki and HUSLAB; Helsinki; Finland

2. Coagulation Disorders; Departments of Clinical Chemistry (HUSLAB) and Hematology (Internal Medicine); Helsinki University Central Hospital; Helsinki; Finland

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcp.12026/fullpdf

Reference39 articles.

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3. Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation;VAN Giezen;J Thromb Haemost,2009

4. Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin;Husted;Eur Heart J,2006

5. Earlier recovery of platelet function after discontinuation of treatment with ticagrelor compared with clopidogrel in patients with high antiplatelet responses;Storey;J Thromb Haemost,2011

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