Affiliation:
1. Park Nicollet Contact Dermatitis Clinic, Department of Dermatology Park Nicollet Health Services/HealthPartners Minneapolis Minnesota USA
2. University of Minnesota Medical School Minneapolis Minnesota USA
3. Department of Dermatology University of Minnesota Minneapolis Minnesota USA
Abstract
AbstractIntroductionAllergic contact dermatitis (ACD) to salicylic acid (SA) is widely unreported. Furthermore, cross‐reactivity between SA and other salicylates has not been reported despite well‐documented in‐group salicylate cross‐reactivity.ObjectiveTo describe our clinic's experience patch testing to SA, highlighting seven cases of relevant reactions and concomitant reactivity with other salicylates.MethodsResults of patch testing to 5% SA in petrolatum between 1 January 2020, and 9 February 2024, are reported. Seven cases of relevant reactions to SA are detailed.ResultsA total of 489 patients (27.5%) were tested to SA, 21 of which were positive: 7 doubtful (+/−), 14 weak positive (+), and no strong/extreme positive reactions. Four irritant reactions were documented. Of the 14 weak positive (+) reactions, 7 had definite or probable clinical relevance, 5 of which also reacted to other salicylates.ConclusionsACD to SA is likely underreported due to a lack of testing. In our experience, testing SA 5% petrolatum is tolerable without significant irritation. Cross‐reactivity between SA and other salicylates is probable. Though SA appears to be the primary sensitizer in some cases, more studies are needed to understand its possible role as a marker for salicylate allergy.