Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates

Author:

Sandu Cristinel1,Chandramouli Nagaranjan2,Glickman Joseph Fraser3,Molina Henrik2,Kuo Chueh-Ling4,Kukushkin Nikolay4,Goldberg Alfred L.4,Steller Hermann1

Affiliation:

1. Howard Hughes Medical Institute; Strang Laboratory of Apoptosis and Cancer Biology; The Rockefeller University; New York NY USA

2. Proteomics Resource Center; The Rockefeller University; New York NY USA

3. High Throughput Screening Resource Center; The Rockefeller University; New York NY USA

4. Department of Cell Biology; Harvard Medical School; Boston MA USA

Funder

H. S.'s Laboratory

NIH

Robertson Foundation

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Reference44 articles.

1. RING domain E3 ubiquitin ligases;Deshaies;Annu Rev Biochem,2009

2. XIAP as a ubiquitin ligase in cellular signaling;Galban;Cell Death Differ,2010

3. The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9;Qiu;J Biol Chem,2005

4. Thiostrepton, a new antibiotic. I. In vitro studies;Donovick;Antibiot Annu,1955

5. Thiostrepton, a new antibiotic. II. Isolation and chemical characterization;Dutcher;Antibiot Annu,1955

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