From convergence insufficiency to functional reorganization: A longitudinal randomized controlled trial of treatment‐induced connectivity plasticity

Abstract

AbstractIntroductionConvergence Insufficiency (CI) is the most prevalent oculomotor dysfunction of binocular vision that negatively impacts quality of life when performing visual near tasks. Decreased resting‐state functional connectivity (RSFC) is reported in the CI participants compared to binocularly normal control participants. Studies report that therapeutic interventions such as office‐based vergence and accommodative therapy (OBVAT) can improve CI participants' clinical signs, visual symptoms, and task‐related functional activity. However, longitudinal studies investigating the RSFC changes after such treatments in participants with CI have not been conducted. This study aimed to investigate the neural basis of OBVAT using RSFC in CI participants compared to the placebo treatment to understand how OBVAT improves visual function and symptoms.MethodsA total of 51 CI participants between 18 and 35 years of age were included in the study and randomly allocated to receive either 12 one‐hour sessions of OBVAT or placebo treatment for 6 to 8 weeks (1 to 2 sessions per week). Resting‐state functional magnetic resonance imaging and clinical assessments were evaluated at baseline and outcome for each treatment group. Region of interest (ROI) analysis was conducted in nine ROIs of the oculomotor vergence network, including the following: cerebellar vermis (CV), frontal eye fields (FEF), supplementary eye fields (SEF), parietal eye fields (PEF), and primary visual cortices (V1). Paired t‐tests assessed RSFC changes in each group. A linear regression analysis was conducted for significant ROI pairs in the group‐level analysis for correlations with clinical measures.ResultsPaired t‐test results showed increased RSFC in 10 ROI pairs after the OBVAT but not placebo treatment (p < 0.05, false discovery rate corrected). These ROI pairs included the following: Left (L)‐SEF–Right (R)‐V1, L‐SEF–CV, R‐SEF–R‐PEF, R‐SEF–L‐V1, R‐SEF–R‐V1, R‐SEF–CV, R‐PEF–CV, L‐V1–CV, R‐V1–CV, and L‐V1–R‐V1. Significant correlations were observed between the RSFC strength of the R‐SEF–R‐PEF ROI pair and the following clinical visual function parameters: positive fusional vergence and near point of convergence (p < 0.05).ConclusionOBVAT, but not placebo treatment, increased the RSFC in the ROIs of the oculomotor vergence network, which was correlated with the improvements in the clinical measures of the CI participants.