Risk factors and early detection of joint damage in patients with psoriasis: a case–control study

Author:

Yao Amin12ORCID,Wang Li3,Qi Fei2,Li Jialu3,Meng Juan4,Jiang Tao3,He Yanling2,Lai Wei1

Affiliation:

1. Department of Dermatology The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China

2. Department of Dermatology Beijing Chao‐yang Hospital, Capital Medical University Beijing China

3. Department of Radiology Beijing Chao‐yang Hospital, Capital Medical University Beijing China

4. Department of Rheumatology Beijing Chao‐yang Hospital, Capital Medical University Beijing China

Abstract

AbstractBackgroundOur aim was to target the unsatisfied need for early detection of the at‐risk population and determine the subgroup of patients whose psoriasis (PsO) could transform into psoriatic arthritis (PsA).MethodsA retrospective and longitudinal case–control study was conducted at Beijing Chao‐yang Hospital. It included 75 patients who were clinically diagnosed with PsA in the case group and 345 who solely suffered from PsO without PsA in the control group. A variety of baseline covariates were gathered from every patient with PsO. Univariate and multivariate analyses and receiver operating characteristic (ROC) curves were used to identify underlying risk factors and determine whether it was necessary to examine the imaging of PsO patients.ResultsIn multivariate logistic regression analysis, age ≥40 (odds ratio (OR): 1.04, 95% confidence interval (CI): 1.02–1.06, P < 0.01), nail involvement (OR: 1.17, 95% CI: 1.09–1.32, P < 0.01), erythrocyte sedimentation rate (ESR) (OR: 1.03, 95% CI: 1.01–1.06, P < 0.05) and elevated high‐sensitivity C‐reactive protein (hs‐CRP) (OR: 1.31, 95% CI: 1.13–1.53, P < 0.01) were perceived to be risk factors for the transformation from PsO into clinical PsA. By combining magnetic resonance imaging (MRI)‐detected enthesitis with tenosynovitis, combined predictors demonstrated better diagnostic efficacy, with an improvement in specificity (94.3% vs. 69%) and similarities in sensitivity (89% vs. 84.6%). The areas under the ROC curve (AUCs) amounted to 0.925 (95% CI: 0.882–0.967, P < 0.01) and 0.858 (95% CI: 0.814–0.903, P < 0.01).ConclusionsIt was identified that age ≥40, nail involvement, as well as an elevated ESR, and hs‐CRP served as independent risk factors for PsO transforming into PsA. Additionally, MRI provides additional value for the early recognition of PsA.

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3