P-glycoprotein in sheep liver and small intestine: gene expression and transport efflux activity

Author:

Ballent M.1,Wilkens M. R.2,Maté L.1,Muscher A. S.2,Virkel G.1,Sallovitz J.1,Schröder B.2,Lanusse C.1,Lifschitz A.1

Affiliation:

1. Facultad de Ciencias Veterinarias; Laboratorio de Farmacología; Centro de Investigación Veterinaria de Tandil (CIVETAN); Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); UNCPBA; Tandil Argentina

2. Department of Physiology; University of Veterinary Medicine Hannover; Hannover Germany

Funder

CONICET

Agencia Nacional de Promoción Científica y Técnica

Ministerio de Ciencia

Tecnología e Innovación Productiva

BMBF

Publisher

Wiley

Subject

General Veterinary,Pharmacology

Reference43 articles.

1. Ketoconazole increases the plasma levels of ivermectin in sheep;Alvinerie;Veterinary Parasitology,2008

2. P-glycoprotein-mediated in vitro biliary excretion in sandwich-cultured rat hepatocytes;Annaert;Drug Metabolism and Disposition,2001

3. Involvement of P-glycoprotein on ivermectin kinetic behaviour in sheep: itraconazole-mediated changes on gastrointestinal disposition;Ballent;Journal of Veterinary Pharmacology and Therapeutics,2007

4. Pretreatment with the inducers rifampicin and phenobarbital alters ivermectin gastrointestinal disposition;Ballent;Journal of Veterinary Pharmacology and Therapeutics,2010

5. The drug transporter-metabolism alliance: uncovering and defining the interplay;Benet;Molecular Pharmacology,2009

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