Meta‐analysis on GLP‐1 mediated modulation of autophagy in islet β‐cells: Prospectus for improved wound healing in type 2 diabetes

Abstract

AbstractType 2 diabetes mellitus refers to a significantly challenging health disease due to its high prevalence and risk of other chronic diseases across the world. Notably, GLP‐1 has been recognized to enhance the treatment of T2DM, along with this, GLP‐1 is also involved in autophagy modulation. However, ineffectiveness of few analogue types can limit the efficacy of this treatment. This study particularly aims to elucidate the influence of GLP‐1 receptor analogues on wound infection and patients with type 2 diabetes. To conduct the meta‐analysis, an expansive literature survey was conducted to unveil the studies and research conducted on T2DM patients that revealed whether the adoption of any GLP‐1 analogue in the form of specific interventions impacts the type 2 diabetes mellitus. The literature was searched using multiple search terms, screened and data were extracted to conduct the meta‐analysis and it was conducted using metabin function of R package meta. A total of 800 patients consisting of the both intervention and control groups were employed to carry out the meta‐analysis to analyse and evaluate the impact of GLP‐1 mediated modulation to improve wound healing in the T2DM patients. The results revealed that GLP‐1 mediated modulation considering one type of analogue was an effective intervention to patients suffering from T2DM. The variations in these results depicted insignificant outcomes with the values (risk ratio [RR]: 1.03, 95% confidence interval [CI]: 0.90–1.18, p > 0.05) and enlightened the fact that adopting different GLP‐1 analogues may significantly improve the efficacy of wound healing in T2DM patients. Hence, interventions of GLP‐1 mediated modulation must be utilized in the clinical practice to reduce the incidence of T2DM patients.