Topical oxygen therapy and singlet oxygen in wound healing: A scoping review

Author:

Sýkorová Martina1ORCID,Moffatt Christine Joy2,Stentiford Neil3,Burian Ewa Anna4ORCID,Katsuhiro Sasagaki5,Wei Yang5

Affiliation:

1. Skin Integrity Research Group School of Health Sciences, University of Nottingham, Queen's Medical Centre Nottingham UK

2. The Institute of Care Excellence, Nottingham University Hospitals NHS Trust, City Hospital Nottingham UK

3. SOE Health Ltd Nottingham UK

4. Department of Dermato‐Venereology and Wound Healing Center Bispebjerg Hospital Copenhagen Denmark

5. Medical Technologies Innovation Facility Engineering Department, School of Science and Technology, Nottingham Trent University Nottingham UK

Abstract

AbstractThe aim of this scoping review was to provide an overview of current research into topical oxygen therapies including the under‐researched singlet oxygen for wound healing. A scoping review was undertaken using five databases. After duplicates and ineligible studies were excluded, 49 studies were included for a narrative review. Out of the included 49 studies, 45 (91.8%) were published in the past 10 years (2013–2023) with 32 (65.3%) published in the past 5 years (2018–2023). Eight of the studies were systematic reviews and/or meta‐analysis and 18 were RCTs. The search identified zero human RCTs on singlet oxygen, but one human cohort study and five studies in animals. There is evidence that topical oxygen therapy may be useful for the treatment of chronic wounds, mainly diabetic foot ulcers. Singlet oxygen has shown potential, but would need further confirmation in controlled human trials, including more research to understand the bio‐properties.

Funder

University of Nottingham

Publisher

Wiley

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