Affiliation:
1. Department of Otorhinolaryngology – Head and Neck Surgery University Medical Center Groningen, University of Groningen Groningen The Netherlands
2. Graduate School of Medical Sciences University of Groningen Groningen The Netherlands
3. Department of Epidemiology University Medical Center Groningen, University of Groningen Groningen The Netherlands
Abstract
AbstractObjectivesExisting knowledge on health‐related quality of life (HRQoL) after surgical removal of sinonasal inverted papilloma (IP) is limited. Moreover, predictors for a better or worse post‐operative HRQoL outcome are not known. Our aim was to assess HRQoL in all three health domains (physical, psychological, and social), track its post‐operative trajectory, investigate if pre‐operative observations could predict distinct post‐operative HRQoL outcomes, and evaluate whether physicians' interventions could contribute to improved post‐operative HRQoL.DesignProspective cohort study.SettingTertiary referral hospital.ParticipantsSeventy‐four patients who underwent surgery for an IP were included. They were asked to fill in the Endonasal Endoscopic Sinus and Skull‐Base Surgery Questionnaire (EES‐Q) pre‐operatively, and then 2 weeks, 3 months, and 1 year post‐operatively.Main Outcome MeasuresLinear mixed models analyses were performed to evaluate the overall post‐operative HRQoL and the separate health domains, as well as the impact of specific variables (sex, age, American Society of Anaesthesiologists [ASA] classification, smoker, Krouse staging, pre‐operative EES‐Q score, type of surgery, and post‐operative antibiotics) on HRQoL improvement.ResultsThe total EES‐Q score (p < .001) as well as the physical (p < .001), psychological (p = .049), and the social (p = .002) domains significantly improved post‐operatively. ASA classification (p = .049), pre‐operative EES‐Q score (p < .001) and post‐operative antibiotics (p = .036) were significant variables.ConclusionsOverall HRQoL, as well as each of the three health domains, improved significantly. A higher ASA score, a higher pre‐operative EES‐Q score, and the administration of post‐operative antibiotics were significant predictors for better HRQoL recovery post‐operatively. Further research is necessary to confirm these results.