Affiliation:
1. Pathology Department School of Medicine, The University of Nottingham, Nottingham University Hospitals NHS Trust Nottingham UK
2. Department of Pathology Hamad Medical Corporation Doha Qatar
3. Irish National Breast Screening Programme and Department of Histopathology St. Vincent's University Hospital Dublin Ireland
4. School of Medicine, University College Dublin Ireland
Abstract
Malignant papillary lesions, and in particular, encapsulated papillary carcinoma (EPC) of the breast, continue to present diagnostic challenges for the practising pathologist. In addition to the relative rarity of these lesions, the lack of evidence‐based diagnostic criteria, differences in the biological characteristics, and the clinical behaviour of in situ and invasive forms, variable use of immunohistochemical markers, and overlap with other tumour types including high‐grade circumscribed forms of invasive breast carcinomas has resulted in diagnostic discordance with potentially significant clinical and management implications. Pathologists should be familiar with the range of morphology observed in malignant papillary tumours, EPC, and EPC‐like tumours and the existence of tumours with overlapping features. In this review we summarize the common diagnostic pitfalls in malignant papillary tumours and provide an approach to the diagnostic evaluation and categorisation of these enigmatic entities.