Resistance mechanism of the oncogenic β3-αC deletion mutation in BRAF kinase to dabrafenib and vemurafenib revealed by molecular dynamics simulations and binding free energy calculations-Reference-Cited by-同舟云学术

Resistance mechanism of the oncogenic β3-αC deletion mutation in BRAF kinase to dabrafenib and vemurafenib revealed by molecular dynamics simulations and binding free energy calculations

Published:2018-10-08 Issue:2 Volume:93 Page:177-187
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Niu Yuzhen¹^ORCID,Zhang Yan²^ORCID,Yao Xiaojun³^ORCID

Affiliation:

1. Shandong Provincial Research Center for Bioinformatic Engineering and Technique; School of Life Sciences; Shandong University of Technology; Zibo China

2. Guiyang College of Traditional Chinese Medicine; Guiyang China

3. Key Lab of Preclinical Study for New Drugs of Gansu Province; Lanzhou University; Lanzhou China

Funder

Natural Foundation of Shandong Province

National Natural Science Foundation of China

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.13399/fullpdf

Reference45 articles.