Structural optimization of diphenylpyrimidine scaffold as potent and selective epidermal growth factor receptor inhibitors against L858R/T790M resistance mutation in nonsmall cell lung cancer-Reference-Cited by-同舟云学术

Structural optimization of diphenylpyrimidine scaffold as potent and selective epidermal growth factor receptor inhibitors against L858R/T790M resistance mutation in nonsmall cell lung cancer

Published:2018-08-26 Issue:6 Volume:92 Page:1988-1997
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Yi Yuanyuan¹,Wang Luhong²,Zhao Dan²,Huang Shanshan²,Wang Changyuan²,Liu Zhihao²³,Sun Huijun²,Liu Kexin²,Ma Xiaodong²^ORCID,Li Yanxia¹

Affiliation:

1. Department of Respiratory Medicine; The First Affiliated Hospital of Dalian Medical University; Dalian China

2. College of Pharmacy; Dalian Medical University; Dalian China

3. State Key Laboratory of Bioactive Substance and Function of Natural Medicines; Institute of Materia Medica; Chinese Academy of Medical Sciences and Peking Union Medical College; Beijing China

Funder

National Natural Science Foundation of China

Research Fund of Higher Education of Liaoning Province

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.13370/fullpdf

Reference32 articles.

1. The next generation of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of lung cancer

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3. FDA Drug Approval Summary: Erlotinib (Tarceva®) Tablets

4. Epidermal Growth Factor Receptor Inhibition in Lung Cancer: Status 2012

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