Overexpressing STAMP2 attenuates adipose tissue angiogenesis and insulin resistance in diabetic ApoE−/− /LDLR−/− mouse via a PPARγ/CD36 pathway

Author:

Wang Feng1,Han Lu2,Qin Ran-ran3,Zhang Yao-yuan1,Wang Di1,Wang Zhi-Hao3,Tang Meng-Xiong4,Zhang Yun1,Zhong Ming1,Zhang Wei1ORCID

Affiliation:

1. The Key Laboratory of Cardiovascular Remodeling and Function Research; Chinese Ministry of Education and Chinese Ministry of Health; The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine; Department of Cardiology; Qilu Hospital of Shandong University; Jinan Shandong China

2. Department of General Practice; Qilu Hospital of Shandong University; Jinan Shandong China

3. Department of Geriatric Medicines; Qilu Hospital of Shandong University; Jinan Shandong China

4. Department of Emergency; Qilu Hospital of Shandong University; Jinan Shandong China

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Key Research and Development Programme of Shandong Province

Natural Science Foundation of Shandong Province

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Reference53 articles.

1. Molecular mechanisms of insulin resistance and the role of the adipocyte;Hotamisligil;Int J Obes Relat Metab Disord,2000

2. Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases;Cao;Nat Rev Drug Discov,2010

3. Adipose tissue angiogenesis: impact on obesity and type-2 diabetes;Corvera;Biochem Biophys Acta,2014

4. Vascular endothelial growth factor is important for brown adipose tissue development and maintenance;Bagchi;Faseb J,2013

5. Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice;Brakenhielm;Circ Res,2004

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