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Preclinical drug evaluation system in the Plasmodium knowlesi baboon model of malaria: the methotrexate study

  • Published:2013-01-07 Issue:2 Volume:42 Page:62-70
  • ISSN:0047-2565
  • Container-title:Journal of Medical Primatology
  • language:en
  • Short-container-title:J Med Primatol

Author:

Ichagichu M.1,Ngotho M.1,Karanja S.M.2,Kokwaro G.3,Kariuki T.1,Nzila A.4,Ozwara H.1

Affiliation:

1. Department of Tropical and Infectious Diseases; Institute of Primate Research; Karen, Nairobi Kenya

2. Institute of Tropical Medicine and Infectious Diseases; Jomo Kenyatta University of Agriculture and Technology; Nairobi Kenya

3. Consortium for National Health Research; Nairobi Kenya

4. Kenya Medical Research Institute (KEMRI) - Wellcome Trust Research Program; Kilifi Kenya

Funder

AntiMal Consortium

Publisher

Wiley

Subject

General Veterinary,Animal Science and Zoology

Reference35 articles.

1. Methotrexate use in rheumatoid arthritis. A Clinician's perspective;Alarcón;Immunopharmacol,2000

2. A research agenda to underpin malaria eradication;Alonso;PLoS Med,2011

3. Biology of human malaria plasmodia including Plasmodium knowlesi;Antinori;Mediterr J Hematol Infect Dis,2012

4. Altered expression of Plasmodium knowlesi variant antigen on the erythrocyte membrane in splenectomized rhesus monkeys;Barnwell;J Immunol,1982

5. A phase i trial to evaluate the safety and pharmacokinetics of low-dose methotrexate as an anti-malarial drug in Kenyan adult healthy volunteers;Chilengo;Malar J,2011

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