Transient loss of satiety effects of leptin in middle‐aged male mice

Author:

Khant Aung Zin1,Ladyman Sharon R.1ORCID,Brown Rosemary S. E.2ORCID

Affiliation:

1. Centre for Neuroendocrinology and Department of Anatomy School of Biomedical Sciences, University of Otago Dunedin New Zealand

2. Centre for Neuroendocrinology and Department of Physiology School of Biomedical Sciences, University of Otago Dunedin New Zealand

Abstract

AbstractExtensive research is undertaken in rodents to determine the mechanism underlying obesity‐induced leptin resistance. While body weight is generally tightly controlled in these studies, the effect of age of experimental animals has received less attention. Specifically, there has been little investigation into leptin regulation of food intake in middle‐aged animals, which is a period of particular relevance for weight gain in humans. We investigated whether the satiety effects of leptin remained constant in young (3 months), middle‐aged (12 months) or aged (18–22 months) male mice. Although mean body weight increased with age, leptin concentrations did not significantly increase in male mice beyond 12 months of age. Exogenous leptin administration led to a significant reduction in food intake in young mice but had no effect on food intake in middle‐aged male mice. This loss of the satiety effect of leptin appeared to be transient, with leptin administration leading to the greatest inhibition of food intake in the aged male mice. Subsequently, we investigated whether these differences were due to changes in leptin transport into the brain with ageing. No change in leptin clearance from the blood or transport into the brain was observed, suggesting the emergence of central resistance to leptin in middle age. These studies demonstrate the presence of dynamic and age‐specific changes in the satiety effects of leptin in male mice and highlight the requirement for age to be carefully considered when undertaking metabolic studies in rodents.

Publisher

Wiley

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Review on the role of hypothalamic astrocytes in the neuroendocrine control of metabolism;Journal of Diabetes & Metabolic Disorders;2024-07-10

2. Obesity's cognitive consequences: leptin's influence on dementia;Journal of Health Sciences and Medicine;2024-05-27

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