Professional continuous glucose monitoring in patients with diabetes mellitus: A systematic review and meta‐analysis

Abstract

AbstractAimTo evaluate the effect on glucose control of professional continuous glucose monitoring (p‐CGM)‐based care as compared with standard care in the management of patients with type 1 and type 2 diabetes.Materials and methodsThe PubMed database was searched comprehensively to identify prospective or retrospective studies evaluating p‐CGM as a diagnostic tool for subsequent implementation of lifestyle and/or medication changes and reporting glycated haemoglobin (HbA1c) as an outcome measure.ResultsWe found 872 articles, 22 of which were included in the meta‐analysis. Overall, the use of p‐CGM was associated with greater HbA1c reduction from baseline (−0.28%, 95% confidence interval [CI] −0.36% to −0.21%, I2 = 0%, P < 0.00001) than usual care, irrespective of type of diabetes, length of follow‐up, frequency of continuous glucose monitoring (CGM) use and duration of CGM recording. In the few studies describing CGM‐derived glucose metrics, p‐CGM showed a beneficial effect on change in time in range from baseline (5.59%, 95% CI 0.12 to 11.06, I2 = 0%, P = 0.05) and a neutral effect on change in time below the target range from baseline (−0.11%, 95% CI −1.76% to 1.55%, I2 = 33%, P = 0.90).ConclusionsIn patients with type 1 and type 2 diabetes, p‐CGM‐driven care is superior to usual care in improving glucose control without increasing hypoglycaemia.