Population pharmacokinetics and pharmacodynamics of Tranexamic acid in women undergoing caesarean delivery

Author:

Li Shuhui1ORCID,Ahmadzia Homa K.2,Guo Dong3,Dahmane Elyes1,Miszta Adam45,Luban Naomi L.C.67,Berger Jeffrey S.8,James Andra H.9,Wolberg Alisa S.4,Anker John N.1011,Gobburu Jogarao V.S.1ORCID

Affiliation:

1. Center for Translational Medicine, School of Pharmacy University of Maryland Baltimore M.D. USA

2. Division of Maternal‐Fetal Medicine, Department of Obstetrics & Gynecology The George Washington University School of Medicine and Health Sciences Washington D.C. USA

3. School of Pharmacy University of Maryland Baltimore M.D. USA

4. Department of Pathology and Laboratory Medicine and UNC Blood Research Center University of North Carolina Chapel Hill N.C. USA

5. Synapse Research Institute Maastricht the Netherlands

6. Division of Hematology Children's National Hospital Washington D.C. USA

7. Department of Pediatrics The George Washington University School of Medicine and Health Sciences Washington DC USA

8. Department of Anesthesiology and Critical Care Medicine The George Washington University School of Medicine and Health Sciences Washington D.C. USA

9. Division of Maternal‐Fetal Medicine, Department of Obstetrics & Gynecology Duke University Durham N.C. USA

10. Division of Clinical Pharmacology Children's National Hospital Washington D.C. USA

11. Division of Pediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel University of Basel Switzerland

Funder

National Institutes of Health

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference30 articles.

1. Trends in Postpartum Hemorrhage in the United States From 2010-2014

2. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial

3. World Health Organization (WHO).Updated WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage: Highlights and Key Messages from the World Health Organization's 2017 Global Recommendation.2017;(October):5.

4. CykloKapron package insert.https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019281s030lbl.pdf. 2012;(11):2012.

5. Tranexamic acid: still far to go

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