Age-related changes of proinsulin processing in diabetic and non-diabetic Japanese individuals

Author:

Yoshino Hiroshi12ORCID,Kawakami Kyoko1,Yoshino Gen1,Hirose Takahisa2

Affiliation:

1. Diabetes Center; Shin-Suma Hospital; Kobe Japan

2. Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine; Toho University Graduate School of Medicine; Tokyo Japan

Publisher

Wiley

Reference21 articles.

1. Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus;Røder;J Clin Endocrinol Metab,1998

2. Estimated proinsulin processing activity of prohormone convertase (PC) 1/3 rather than PC2 is decreased in pancreatic β-cells of type 2 diabetic patients;Ozawa;Endocr J,2014

3. What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism;Rhodes;Diabetes,1994

4. A basic study of the intact proinsulin assay reagent;Koyama;JJCLA,2006

5. Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr;Harris;Diabetes,1987

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