Affiliation:
1. Department of Occupational and Environment Health Xiangya School of Public Health Central South University Changsha China
2. Department of General Surgery Xiangya Hospital Central South University Changsha China
3. Hunan Provincial Key Laboratory of Clinical Epidemiology Central South University Changsha China
Abstract
Abstract
Necrotizing enterocolitis (NEC) is a digestive disease that frequently occurs in premature infants with low gestational age and low birth weight, and seriously threatens the life of NEC patients. NEC pathogenesis is recognized to be affected by multiple factors, such as preterm birth, formula feeding and low birth weight. As a popular object for the past decades, intestinal flora is commonly used in NEC-related studies, and intestinal disorder is considered as a critical risk factor for the occurrence and development of NEC. The colonization of abnormal microbiota into gastrointestinal micro-ecosystem can easily lead to the damage of intestinal mucosal barrier, destruction of immune function, inflammatory reaction and further the occurrence of NEC. Although it is a low-cost and safe way to prevent and treat the NEC by early intervention of oral probiotics to regulate the intestinal homoeostasis, more studies in the future are still encouraged to narrow the gap between theoretical guidance and practical application.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Hunan Province
Science and Technology Plan Project for Natural Resources of Hunan Province
Publisher
Oxford University Press (OUP)
Subject
Applied Microbiology and Biotechnology
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