Antibodies against the majority subunit of type IV pili disperse nontypeableHaemophilus influenzaebiofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media-Reference-Cited by-同舟云学术

Antibodies against the majority subunit of type IV pili disperse nontypeableHaemophilus influenzaebiofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media

Published:2015-02-15 Issue:2 Volume:96 Page:276-292
ISSN:0950-382X
Container-title:Molecular Microbiology
language:en
Short-container-title:Molecular Microbiology

Author:

Novotny Laura A.¹²,Jurcisek Joseph A.¹²,Ward Michael O.¹²,Jordan Zachary B.¹²,Goodman Steven D.¹²,Bakaletz Lauren O.¹²

Affiliation:

1. Center for Microbial Pathogenesis; The Research Institute at Nationwide Children's Hospital; 700 Children's Drive Columbus OH 43205 USA

2. The Ohio State University College of Medicine; Columbus OH 43210 USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Molecular Biology,Microbiology

Reference36 articles.

1. LuxS promotes biofilm maturation and persistence of nontypeable Haemophilus influenzae in vivo via modulation of lipooligosaccharides on the bacterial surface;Armbruster;Infect Immun,2009

2. RbsB (NTHI_0632) mediates quorum signal uptake in nontypeable Haemophilus influenzae strain 86-028NP;Armbruster;Mol Microbiol,2011

3. Bacterial biofilms in the upper airway - evidence for role in pathology and implications for treatment of otitis media;Bakaletz;Paediatr Respir Rev,2012

4. Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection;Bakaletz;Infect Immun,1999

5. Demonstration of type IV pilus expression and a twitching phenotype by Haemophilus influenzae;Bakaletz;Infect Immun,2005

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